How Stratamed works

Faster re-epithelialization of the wound bed

Stratamed’s protective and hydrophobic film has a semi-occlusive effect and therefore improves the tissue hydration of the injured skin area. This environment allows a faster migration of keratinocytes across the wound bed and supports a more rapid re-epithelization and effective healing. The faster re-epithelialization dramatically decreases the incidence of abnormal scarring1,2 and gives patients a faster recovery time.

Reduction of inflammatory response

Stratamed forms a flexible, protective sheet that is gas permeable but semi-occlusive, which weakly bonds to the injured skin and protects it from chemical and microbial invasion, but it does not penetrate into the epidermis or dermis.1 The polymers Stratamed contains have no measurable pH value, and therefore do not affect the protective acid mantle of the skin and do not react with the newly forming epithelial tissues.1 This leads to a reduction in the inflammatory response (redness/discoloration, burning sensation, itching, discomfort, pain etc), and effective healing of the wound, therefore enhancing therapeutic results.1

Abnormal scar management

After the re-epithelialization of a wound, the stratum corneum is immature and still allows abnormally high levels of Trans-Epidermal Water Loss (TEWL). Dehydration is signaled to keratinocytes, which then start to produce cytokines, which in epidermal-dermal signaling activate dermal fibroblasts to synthesize and release collagen. Excessive collagen production leads to abnormal scarring.1

At this wound healing stage, the Stratamed layer restores the barrier function of the stratum corneum, reduces TEWL, and stops dehydration of the skin. Reduction of TEWL turns off the stimulation of keratinocytes and the production of cytokines, thus normalizing the level of collagen production, resulting in a normal mature scar.3

1. Sandhofer M, Schauer P. Skinmed 2012; 10(6):1–7
2. Monk EC et al. Dermatol Surg 2014; 40:76–79
3. Mustoe TA. Aesth Plast Surg 2008; 32:82–92